The purpose of our study was to compare the efficacy and safety of Clonidine to that of Ketamine added to 0.25% ropivacaine for caudal analgesia in children. Settings and Design: prospective, double blind randomized controlled trial. Material and Methods:
Sixty children in the age group of 1 – 8 years undergoing sub umbilical surgeries were included in the study. After induction with general anaesthesia, caudal block was given with injection Ropivacaine 0.25% 1ml/kg and Clonidine 1µg/kg in group RC and injection Ropivacaine 0.25% 1 ml/kg and Ketamine 0.5 mg/kg in group RK. Results:
The mean duration of analgesia was 530±44.2 mins in RC group as compared to 395±43.4 mins in RK group. The duration of analgesia was significantly prolonged in group RC with p value of 0.000. The mean pain score of RK group was higher than RC group at 6th
(3.5±0.57 vs. 3.0±0.37) and 8th
hour (3.93±0.25vs3.63±0.49) postoperatively which was statistically significant. There was no significant difference between the two groups with respect to haemodynamic parameters as only one patient had bradycardia in RC group. Conclusion:
Ropivacaine (0.25%) with Clonidine (1µg/kg) in caudal block significantly prolongs the duration of analgesia compared to Ropivacaine (0.25%) with Ketamine (0.5mg/kg), without any adverse effects, can be used safely in paediatric caudal block.
Dr. Ankita Nathani, Dr. Sanhita kulkarni, Dr. Vasanti Kelkar, Dr. Pradnya Joshi. Comparati Ive study of caudal Clonidiine with ketamine added to ropivacaine in pediatrics for below umbilical surgeries. Int. J. Anesthesiology Res. 2019;1(1):09-13.