Inadequate pain control after lumbar disc herniation surgeries may increase morbidity; leading to prolonged hospital stays, and increase medical costs. The anti-epileptic drugs such as gabapentin and other non-steroidal anti-inflammatory drugs (NSAID) such as celecoxib were used as a part of multimodal analgesia to control such pain. Aim of the study
; The aim of this randomized double-blinded study was to asses and compare the efficacy of using gabapentin versus celecoxib as a part of multi modal analgesia in perioperative hemodynamic control and pain relief in patients underwent posterior approach lumbar spine disc surgery. Methods:
A prospective, comparative blinded randomized study was carried out on one hundred patients of both gender, ASA I and II, aged between 21-60 years old scheduled to undergo elective posterior approach lumbar spine disc surgery. Patients were randomly assigned into two groups (50 patients each); Group (G) received gabapentin 300 mg capsule 2 hours preoperative and the same dose 6 hours postoperative and Group (C) received celecoxib 200 mg 2 hours preoperative and the same dose 6 hours postoperative. Intra operative hemodynamics and post-operative following parameters were recorded; mean arterial pressure, heart rate, respiratory rate, Visual Analogue score and Patient satisfaction score: at the end of postoperative period. Results:
No significant difference was found in demographic data between both groups. Gabapentin administration associated with a better control of intra and post-operative mean arterial pressure and heart rate P values were (p<0.016) (p<0.018) respectively when compared to celecoxib. Regarding VAS scores in both groups there was decrease but more significant in Group (G) especially in first 8 hours (p<0.001). the same as satisfaction score. Conclusion:
We concluded that both Gabapentin and celecoxib provide pain relief and good hemodynamic control when administered perioperatively but Gabapentin provide much better patient’s satisfaction after elective spine fixation surgeries.
Al Shimaa Ismael Roushdy, Khaled Ahmed Abdou, Alaa Ali M Elzohry. Safety of gabapentin versus celecoxib as a part of multimodal analgesia in patients with elective spine fixation surgery, A comparative randomized control study. Int. J. Anesthesiology Res. 2020;2(1):16-21.