Vol. 5, Issue 2, Part A (2023)

Background: To evaluate hyperglycaemic response to an anti-emetic dose of dexamethasone in diabetic subjects undergoing Cholecystectomy surgery.
Materials and Methods: A prospective study was conducted, over 120 ASA I and II, aged 16-60 years patients posted for Cholecystectomy under General Anaesthesia for a period of October 2021 to October 2022. Prior to the anaesthetic induction, diabetic and non-diabetic patients were randomly distributed by numbers generated computationally in two groups: Group A, 60 diabetic patients received 8 mg dexamethasone. Group B, 60 non-diabetic patients received 8 mg dexamethasone. Data were analysed using Statistical Package for Social Sciences, version 23 (SPSS Inc., Chicago, IL). Student t-test was used for group comparison. A p-value of <0.05 was considered statistically significant.
Results: The distribution of studied patients was based on a comparison of duration of surgery in both groups and it was observed that the mean duration of surgery in group A and group B was 2.0±0.0 min and 2.0±0.0 min respectively. 
Conclusion: Dexamethasone caused a significant rise in blood sugar in diabetic patients but the hyperglycaemic response was not exaggerated beyond expected physiology, so no pharmacological intervention was required.