Vol. 7, Issue 2, Part A (2025)

Background: After a laparoscopic cholecystectomy (LC), postoperative pain is still a major issue even though the procedure is less invasive. Intraperitoneal instillation of local anesthetics such as bupivacaine is commonly used for pain control. However, the impact of dilution on analgesic efficacy remains unclear.

Methods: Seventy adult patients receiving elective LC were included in this prospective single-blind randomized controlled research. Patients were randomly allocated to one of two groups: Group A received 20 ml of 0.5% undiluted bupivacaine, and the same dosage was given to Group B, diluted in 480 milliliters of saline.

Results: The amount of fentanyl consumed during surgery didn't change considerably in between the two groups. Compared to group A, group B's time to first request rescue analgesia was noticeably delayed (p<0.001). Group B consumed far less tramadol overall within the first twenty-four hours than group A (p<0.001). Group B's VAS score was considerably lower than group A's at 2, 4, 6, and 12 hours, while There wasn't any noteworthy difference between the two groups' scores at PACU and 24 hours (p<0.05).

Conclusions: Intraperitoneal instillation of diluted bupivacaine provides more prolonged and effective postoperative analgesia, reduces early pain intensity and opioid requirements, without increasing adverse events, compared to the same dose of non‑diluted bupivacaine.